Important update: Healthcare facilities
CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. Learn more
UPDATE
Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the guidance for fully vaccinated people. CDC recommends universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status. Children should return to full-time in-person learning in the fall with layered prevention strategies in place.
UPDATE
The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. For purposes of entry into the United States, vaccines accepted will include FDA approved or authorized and WHO Emergency Use Listing vaccines. More information is available here.

Clinical Course: Progression, Management, and Treatment

Clinical Course: Progression, Management, and Treatment

Clinical considerations for care of children and adults with confirmed COVID-19

Updated Jan. 9, 2024

The content of this page is being updated to reflect FDA's emergency use authorization for Pemgarda (pemivibart), a monoclonal antibody for pre-exposure prevention of COVID-19 in people ages 12 years and older who are moderately to severely immunocompromised. Pemgarda is not a substitute for COVID-19 vaccination and provides additional protection even among people who have received the vaccine. Learn more.

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What You Need to Know
  • The clinical spectrum of SARS-CoV-2 infection includes asymptomatic infection and mild, moderate, severe, and critical illness.
  • Information about clinical management and treatment of COVID-19 is categorized by severity of illness.
  • Most patients with mild or moderate COVID-19 can be managed in an outpatient setting.
  • Most patients with severe or critical COVID-19 illness require hospitalization.

Mild to Moderate Illness

Most patients with COVID-19 experience asymptomatic SARS-CoV-2, or mild to moderate illness that can be managed in the outpatient setting.

Severe to Critical Illness

Table of Contents

References